Background and Objectives: Alopecia areata is a common disease, which causes significant cosmetic and psycho-social distress for most of the people it affects. The most evidence-based hypothesis is an autoimmune reaction caused by the loss of hair follicle immune privilege. Immune privilege loss is assumed to be either a primary event that triggers antigen presentation in a disturbed hair follicle environment or an event that occurs as a result of central immune system dysregulation that involves the follicles. Several gene loci have been identified with alopecia areata. In this study, we report an innovative form of treatment with AAPE in a patient with advanced chronic alopecia areata.   Study Design/Patients and Methods: In this case report, I have investigated the therapeutic effect of a single treatment session using AAPE in a female patient with a challenging form of alopecia areata. Results: Treating the patient with AAPE resulted in no adverse effects after the session, significant satisfactory regrowth of healthy hair in the entire treated area. In the six months follow-up period, there was no evidence of relapse in the treated areas. Conclusions: Intradermal application of AAPE has been proved to be successful, safe treatment and easy to apply. The recovery was very satisfying even after 6 months post AAPE only.